Chem. Pharm. Bull., 49(5),551-557, May 2001

Regular Articles

Studies on the Constituents of Bark of Parameria laevigata MOLDENKE ¹⁾

Kohei KAMIYA, ^a,b Chiharu WATANABE,^a Hanani ENDANG,^c Mansur UMAR,^c and Toshiko SATAKE^*,a,b

Faculty of Pharmaceutical Sciences ^a and High Technology Research Center,^b Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan and Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Indonesia,^c Depok-Jawa Barat, Indonesia

One new trimeric proanthocyanidin, epicatechin-(2bO7,4b6)-epicatechin-(2bO7, 4b8)-epicatechin (5) and two new tetrameric proanthocyanidins, epicatechin-(2bO7, 4b8)-[epicatechin-(4b6)]-epicatechin-(4b8)-epicatechin, named as parameritannin A-1 (6), and epicatechin-(2bO5, 4b6)-[epicatechin-(2bO7, 4b8)]-epicatechin-(4b8)-epicatechin, named as parameritannin A-2 (7), have been isolated from the bark of Parameria laevigata Moldenke (Apocynaceae) along with the two known dimers, proanthocyanidin A-2 (1) and proanthocyanidin A-6 (2), and two trimers, cinnamtannin B-1 (3) and aesculitannin B (4). These structures were elucidated by spectral and chemical evidence.

Key words Parameria laevigata; proanthocyanidin; parameritannin; doubly linked structure; thiolytic degradation; Apocynaceae