Chem. Pharm. Bull., 50(2),268-271, February 2002

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Ent-kaurane Diterpenoid Glycosides from the Leaves of Cussonia racemosa, a Malagasy Endemic Plant

Liva Rakotondraibe Romuald HARINANTENAINA, Ryoji KASAI, and Kazuo YAMASAKI*

Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Six new ent-kaurane diterpenoid glycosides, cussoracosides A (3), B (4), C (5), D (6), E (7), and F (8) were isolated from the dried leaves of Cussonia racemosa, along with two known compounds identified as b-D-glucopyranosyl ent-16b, 17-dihydroxykauran-19-oate (1) and paniculoside IV (2). The structures of these new compounds were deduced on the basis of chemical and spectroscopic evidence.

Key words Cussonia racemosa; Araliaceae; cussoracoside; Kaurane-type diterpenoid glycoside; sweet glycoside