Chem. Pharm. Bull., 51(7),854-856, July 2003

Notes

A New Chalcone and a Flavone from Andrographis neesiana

Muntha KESAVA REDDY,^a Mopuru VIJAYA BHASKAR REDDY,^a Bandi ANIL KUMAR REDDY,^a Duvvuru GUNASEKAR,^*,a Cristelle CAUX,^b and Bernard BODO^b

^a Natural Products Division, Department of Chemistry, Sri Venkateswara University; Tirupati 517 502, India: and ^b Laboratoire de Chimie des Substances Naturelles, ESA 8041 CNRS, Museum National d'Histoire Naturelle; 63 rue Buffon, 75005 Paris, France. * To whom correspondence should be addressed. e-mail: duvvurusekarg@rediffmail.com

Two new flavonoids, 2′,4′,6′,2,3,4-hexamethoxychalcone (1) and 5-hydroxy-7,2′,5′-trimethoxyflavone (2) together with a known flavone glycoside, echioidinin 5-O-β-D-glucopyranoside (3) were isolated from the whole plant of Andrographis neesiana, and the structures were elucidated by electrospray ionization tandem mass spectrometry (ESI-MS/MS) and one- and two-dimensional (1D- and 2D)-NMR spectral studies including ¹H-¹H correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and nuclear Overhauser enhancement spectroscopy (NOESY) experiments.

Key words Andrographis neesiana; Acanthaceae; flavonoid