Chem. Pharm. Bull., 53(7),776-779, July 2005

Regular Articles

Antimitotic and Antifungal C-3/C-3″-Biflavanones from Stellera chamaejasme

Guohong YANG,^a Zhixin LIAO,^a Zhiyong XU,^b Huiping ZHANG,^b and Daofeng CHEN^*,a

^a Department of Pharmacognosy, School of Pharmacy, Fudan University; and ^b Department of Chemistry of Natural Drugs, School of Pharmacy, Fudan University; 138 Yixueyuan Road, Shanghai 200032, People's Republic of China. * To whom correspondence should be addressed. e-mail: dfchen@shmu.edu.cn

Two new C-3/C-3″ biflavanones, chamaejasmenin D (1) and isochamaejasmenin B (2), were isolated from the roots of Stellera chamaejasme, together with five known biflavanones, chamaejasmenin A (3), chamaejasmenin B (4), neochamaejasmin A (5), sikokianin A (6), and chamaejasmenin C (7). Their structures were elucidated by spectroscopic methods, including 2D NMR techniques. Among these compounds, 1-3 demonstrated potent antimitotic and antifungal activity with minimum inhibitory concentration (MIC) values of 6.25, 6.25, and 3.12 μg/ml, respectively.

Key words Stellera chamaejasme; chamaejasmenin D; isochamaejasmenin B; antimitotic; antifungal; Pyricularia oryzae