Chem. Pharm. Bull., 53(7),783-787, July 2005

Regular Articles

A Monoterpene Glucoside and Three Megastigmane Glycosides from Juniperus communis var. depressa

Tsutomu NAKANISHI,^*,a Naoki IIDA,^a Yuka INATOMI,^a Hiroko MURATA,^a Akira INADA,^a Jin MURATA,^b Frank A. LANG,^c Munekazu IINUMA,^d Toshiyuki TANAKA,^e and Yoshikazu SAKAGAMI^f

^a Faculty of Pharmaceutical Sciences, Setsunan University; 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan: ^b Botanical Gardens, Koishikawa, Graduate School of Science, The University of Tokyo; 3-7-1 Hakusan, Bunkyo-ku, Tokyo 112-0001, Japan: ^c Department of Biology, Southern Oregon University; 1250 Siskiyou, Ashland, OR 97520-5071, U.S.A.: ^d Gifu Pharmaceutical University; 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan: ^e Gifu Prefectural Institute of Health and Environmental Sciences; 1-1 Naka Fudogaoka, Kakamigahara, Gifu 504-0838, Japan: and ^f Osaka Prefectural Institute of Public Health; 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. * To whom correspondence should be addressed. e-mail: nakanisi@pharm.setsunan.ac.jp

A new monoterpene glucoside (1) and three new natural megastigmane glycosides (2-4) were isolated along with a known megastigmane glucoside (5) from twigs with leaves of Juniperus communis var. depressa (Cupressaceae) collected in Oregon, U.S.A., and their structures were determined on the basis of spectral and chemical evidence. In addition, the antibacterial activities of the isolated components against Helicobacter pylori were also investigated.

Key words Juniperus communis var. depressa; monoterpene glucoside; megastigmane glycoside; Helicobacter pylori; Cupressaceae