Chem. Pharm. Bull., 53(7),808-810, July 2005

Regular Articles

New Bicyclic Taxane Diterpenoids from Taxus sumatrana

Ya-Ching SHEN,^*,a Shaw-Man HSU,^a,d Yun-Sheng LIN,^a Kuen-Ching CHENG,^a Ching-Te CHIEN,^b Chang-Hung CHOU,^c,d and Yuan-Bin CHENG^a

^a Institute of Marine Resources, National Sun Yat-sen University; 70 Lien-Hai Road, Kaohsiung, 80424, Taiwan, Republic of China: ^b Division of Silviculture, Taiwan Forestry Research Institute; 53 Nan-Hai Road, Taipei, Taiwan, Republic of China: ^c National Pingtung University of Science and Technology; Pingtung, 912, Taiwan, Republic of China: and ^d Institute of Biology, National Sun Yat-sen University; Taiwan, Republic of China. * To whom correspondence should be addressed. e-mail: ycshen@mail.nsysu.edu.tw

Investigation of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of two new bicyclic taxoids, tasumatrols M (1), and N (2) and a new baccatin III derivative, tasumatrol O (3) together with the previous known 7-deacetylcanadensene (4) and 2α,7β,13α-triacetoxy-5α,9α-dihydroxy-2(3→20) abeotaxa-4(20),11-dien-10-one. The structures of these taxanes were established on the basis of spectroscopic analyses, especially 1- and 2D NMR, and chemical derivatization.

Key words Taxaceae; Taxus sumatrana; taxane diterpene