Chem. Pharm. Bull., 53(7),841-842, July 2005

Notes

Two New Sesquiterpene Lactones with the Sulfonic Acid Group from Saussurea lappa

Hong-quan YIN,^a Hong-wei FU,^a Hui-ming HUA,^a Xiu-lan QI,^b Wen LI,^c Yi SHA,^c and Yue-hu PEI^*,a

^a School of Traditional Chinese Medicine, Shenyang Pharmaceutical University; Shenyang 110016, China: ^b School of Pharmaceutical Engineering, Shenyang Pharmaceutical University; Shenyang 110016, China: and ^c Department of Instrumental Analysis, Shenyang Pharmaceutical University; Shenyang 110016, China. * To whom correspondence should be addressed. e-mail: peiyueh@vip.163.com

Two new sesquiterpene lactones with the unusual sulfonic acid group, 13-sulfo-dihydrosantamarine (1) and 13-sulfo-dihydroreynosin (2), have been isolated from the roots of Saussurea lappa C. Their structures, including the absolute configurations, were elucidated by spectroscopic methods.

Key words Saussurea lappa C; Compositae; sesquiterpene lactone; 13-sulfo-dihydrosantamarine; 13-sulfo-dihydroreynosin