Chem. Pharm. Bull., 53(7),850-852, July 2005

Notes

Antibacterial Caged-Tetraprenylated Xanthones from the Fruits of Garcinia hanburyi

Yaowapa SUKPONDMA,^a Vatcharin RUKACHAISIRIKUL,^*,a and Souwalak PHONGPAICHIT^b

^a Department of Chemistry, Faculty of Science, Prince of Songkla University; Songkhla, 90112, Thailand: and ^b Department of Microbiology, Faculty of Science, Prince of Songkla University; Songkhla, 90112, Thailand. * To whom correspondence should be addressed. e-mail: vatcharin.r@psu.ac.th

A new caged-tetraprenylated xanthone, hanburinone (1), was isolated from the fresh fruits of Garcinia hanburyi together with four known caged-tetraprenylated xanthones; isomoreollin B (2), morellin (3), moreollic acid (4) and morellic acid (5). Their structures were elucidated by analysis of spectroscopic data and comparison of the NMR data with those reported previously. Compounds 4 and 5 showed moderately antibacterial activity against methicillin-resistant Staphylococcus aureus with a MIC value of 25 μg/ml.

Key words Garcinia hanburyi; Guttiferae; caged-tetraprenylated xanthone; antibacterial activity