Chem. Pharm. Bull., 47(1), 96-100, January 1999

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Antiproliferative Constituents from Umbelliferae Plants. V.¹⁾ A New Furanocoumarin and Falcarindiol Furanocoumarin Ethers from the Root of Angelica japonica

Toshihiro FUJIOKA,^a Kazuhiro FURUMI,^a Hiroko FUJII,^a Hikaru OKABE,^a Kunihide MIHASHI,^*,a Yukitaka NAKANO,^b Hisashi MATSUNAGA,^b Mitsuo KATANO,^c and Masato MORI^b

Faculty of Pharmaceutical Sciences, Fukuoka University,^a 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, Faculty of Hospital Pharmacy,^b and Department of Surgery,^c Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
Received September 3, 1998; accepted October 14, 1998

The CHCl₃ extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylhamaudol, and hamaudol). The structures of the new isolates were determined based on spectral evidence. The ED₅₀ of isolates against MK-1, HeLa, and B16F10 cell lines are reported.

Key words Angelica japonica; Umbelliferae; antiproliferative constituent; furanocoumarin; japoangelol; falcarindiol furanocoumarin ethers