Chem. Pharm. Bull., 52(5),615-617, May 2004

Notes

Antioxidative Phenylethanoid and Phenolic Glycosides from Picrorhiza scrophulariiflora

Hao WANG,^a Yang SUN,^b Wen-Cai YE,^*,a,c Fei XIONG,^d Jia-Jun WU,^a Chun-Hua YANG,^a and Shou-Xun ZHAO^a

^a Department of Phytochemistry, China Pharmaceutical University; ^b Department of Pharmacology for Chinese Materia Medica, China Pharmaceutical University; ^d Pharmaceutical Institute, China Pharmaceutical University; Nanjing 210009, P. R. China: and ^c Institute of Traditional Chinese Medicine and Natural Products, Jinan University; Guangzhou 510632, P. R. China. * To whom correspondence should be addressed. e-mail: chywc@yahoo.com.cn

One new phenylenthanoid glycoside, scroside D (2), was isolated from the roots of Picrorhiza scrophulariiflora (Scrophulariaceae), together with nine known phenylethanoid and phenolic glycosides: 2-(3,4-dihydroxyphenyl)-ethyl-O-β-D-glucopyranoside (1), 2-(3-hydroxy-4-methoxyphenyl)-ethyl-O-β-D-glucopyranosyl (1→3)-β-D-glucopyranoside (3), scroside B (4), hemiphroside A (5), plantainoside D (6), scroside A (7), androsin (8), piceoside (9), and 6-O-feruloyl-β-D-glucopyranoside (10). The structures of these compounds were elucidated using spectroscopic methods. The antioxidative activities of these isolated compounds were evaluated based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. Compounds 1, 2, and 6 showed potent antioxidative effects as those of ascorbic acid and the structure-activity relationship is discussed.

Key words Picrorhiza scrophulariiflora; Scrophulariaceae; phenylethanoid glycoside; phenolic glycoside; antioxidative activity