Chem. Pharm. Bull.

Chem. Pharm. Bull., 53(8),1051-1053, August 2005

Notes

Novel Phenolic Glycoside Dimer and Trimer from the Whole Herb of Pyrola rotundifolia

Jun CHANG^* and Taichi INUI

Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, University of Illinois at Chicago; 833 South Wood Street, Chicago, Illinois 60612, U.S.A. * To whom correspondence should be addressed. e-mail: jch1@uic.edu

From the water-soluble constituents of the whole herb of Pyrola rotundifolia (Pyrolaceae), one novel phenolic glycoside dimer, pyrolaside A (1), and one novel phenolic glycoside trimer, pyrolaside B (2), together with two known phenolic glycosides homoarbutin (3) and isohomoarbutin (4), were isolated. The structures were elucidated by spectroscopic analysis and confirmed with chemical degradation. In vitro tests for antimicrobial activity showed pyrolaside B (2) to possess significant activity against two Gram-positive organisms, Staphylococcus aureus and Micrococcus luteus.

Key words Pyrola rotundifolia; Pyrolaceae; phenolic glycoside dimer; phenolic glycoside trimer; antimicrobial activity

Notes

Novel Phenolic Glycoside Dimer and Trimer from the Whole Herb of Pyrola rotundifolia

Jun CHANG* and Taichi INUI

Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, University of Illinois at Chicago; 833 South Wood Street, Chicago, Illinois 60612, U.S.A. * To whom correspondence should be addressed. e-mail: jch1@uic.edu

Jun CHANG^* and Taichi INUI