Chem. Pharm. Bull., 53(8),1065-1067, August 2005

Notes

Antioxidative Phenols and Phenolic Glycosides from Curculigo orchioides

Qiong WU,^a,b Da-Xu FU,^a,b Ai-Jun HOU,^a,c Guang-Qing LEI,^a,b Zhi-Jun LIU,^d Jia-Kuan CHEN,^a,b and Tong-Shui ZHOU^*,a,b

^a Research Center of Natural Medicines, Fudan University; ^b School of Life Sciences, Fudan University; ^c Department of Pharmacognosy, School of Phamacy, Fudan University; Shanghai 200433, P. R. China: and ^d Medicinal Plant Laboratory, School of Renewable Natural Resources, Louisiana State University Agricultural Center; Baton Rouge, LA 70803, U.S.A. * To whom correspondence should be addressed. e-mail: tszhou@fudan.edu.cn

A new orcinol glucoside, orcinol-1-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (3), was isolated from the rhizomes of Curculigo orchioides GAERTN., together with seven known compounds: orcinol glucoside (1), orcinol-1-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (2), curculigoside (4), curculigoside B (5), curculigoside C (6), 2,6-dimethoxyl benzoic acid (7), and syringic acid (8). The structures of these compounds were elucidated using spectroscopic methods. The antioxidant activities of these isolated compounds were evaluated by colorimetric methods based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. All the compounds showed potent antioxidative activities and the structure-activity relationship is discussed.

Key words Curculigo orchiodes; Hypoxidaceae; phenol; phenolic glycoside; antioxidative activity