Chem. Pharm. Bull., 54(3),380-383, March 2006

Notes

New Neolignans and Lignans from Vietnamese Medicinal Plant Machilus odoratissima NEES

PHAN Minh Giang,^a,b PHAN Tong Son,^a Katsuyoshi MATSUNAMI,^b and Hideaki OTSUKA^*,b

^a Faculty of Chemistry, College of Natural Science, Vietnam National University; 19 Le Thanh Tong Street, Hanoi, Vietnam: and ^b Graduate School of Biomedical Sciences, Hiroshima University; 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. * To whom correspondence should be addressed. e-mail: hotsuka@hiroshima-u.ac.jp

Four new natural neolignans and lignans, which were given the trivial names odoratisols A-D (1-4), together with (−)-licarin A, kachirachirol B, obovatifol, and machilin-I were isolated from the air-dried bark of the Vietnamese medicinal plant Machilius odoratissima NEES (Lauraceae). Their absolute structures were determined on the basis of spectroscopic analyses including circular dichroism spectra.

Key words Machilus odoratissima; Lauraceae; neolignan; lignan; odoratisol; absolute structure