Chem. Pharm. Bull.

Chem. Pharm. Bull., 56(9),1270-1275, September 2008

Regular Articles

Chemical Constituents from the Leaves of Manglietia phuthoensis and Their Effects on Osteoblastic MC3T3-E1 Cells

Phan Van KIEM,^a Mai Dinh TRI,^a Le Vo Dinh TUONG,^a Nguyen Huu TUNG,^a,c Nguyen Ngoc HANH,^b Tran Hong QUANG,^a Nguyen Xuan CUONG,^a Chau Van MINH,^a Eun-Mi CHOI,^c and Young Ho KIM^*,c

^a Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology; 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam: ^b Institute of Chemical Technology; 1 Mac Dinh Chi, Ho Chi Minh, Vietnam: and ^c College of Pharmacy, Chungnam National University; Daejeon 305-764, Korea. * To whom correspondence should be addressed. e-mail: yhk@cnu.ac.kr

Two new phenyl glycosides, mangliesides A and B (1, 2), a new ionol glycoside, manglieside C (3), two new lignan glycosides, mangliesides D and E (4, 5), were isolated from the leaves of Manglietia phuthoensis, along with two known lignans, 3-methoxymagnolol (6) and obovatol (7). Their structures were established by means of 1D and 2D NMR, electrospray ionization (ESI)-MS and HR-ESI-MS experiments. Among them, compounds 2 and 5 significantly (p<0.05) increased the growth and differentiation of osteoblastic MC3T3-E1 cells in vitro.

Key words Manglietia phuthoensis; manglieside A; manglieside B; manglieside C; manglieside D; manglieside E

Regular Articles

Chemical Constituents from the Leaves of Manglietia phuthoensis and Their Effects on Osteoblastic MC3T3-E1 Cells

Phan Van KIEM,a Mai Dinh TRI,a Le Vo Dinh TUONG,a Nguyen Huu TUNG,a,c Nguyen Ngoc HANH,b Tran Hong QUANG,a Nguyen Xuan CUONG,a Chau Van MINH,a Eun-Mi CHOI,c and Young Ho KIM*,c

Phan Van KIEM,^a Mai Dinh TRI,^a Le Vo Dinh TUONG,^a Nguyen Huu TUNG,^a,c Nguyen Ngoc HANH,^b Tran Hong QUANG,^a Nguyen Xuan CUONG,^a Chau Van MINH,^a Eun-Mi CHOI,^c and Young Ho KIM^*,c