Chem. Pharm. Bull.

Chem. Pharm. Bull., 59(4),511-514, April 2011

Note

Fischerisin A and B, Cytotoxic Sesquiterpenoid-Geranylhydroquinones from Ligularia fischeri

Wei-Dong XIE,^*,a Xia LI,^a Cheng-Wu WENG,^a Shan-Shan LIU,^a and Kyung Ho ROW^b

^a Marine College, Shandong University at Weihai; Weihai 264209, P. R. China: and ^b Department of Chemical Engineering, Inha University; Incheon 402751, Korea. * To whom correspondence should be addressed. e-mail: wdxie@sdu.edu.cn

During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC₅₀ values of 9.7 and 10.2 μM, and 9.8 and 17.8 μM, respectively.

Key words Ligularia fischeri; sesquiterpenoid; geranylhydroquinone; cytotoxicity; fischerisin A; fischerisin B

Note

Fischerisin A and B, Cytotoxic Sesquiterpenoid-Geranylhydroquinones from Ligularia fischeri

Wei-Dong XIE,*,a Xia LI,a Cheng-Wu WENG,a Shan-Shan LIU,a and Kyung Ho ROWb

a Marine College, Shandong University at Weihai; Weihai 264209, P. R. China: and b Department of Chemical Engineering, Inha University; Incheon 402751, Korea. * To whom correspondence should be addressed. e-mail: wdxie@sdu.edu.cn

Wei-Dong XIE,^*,a Xia LI,^a Cheng-Wu WENG,^a Shan-Shan LIU,^a and Kyung Ho ROW^b

^a Marine College, Shandong University at Weihai; Weihai 264209, P. R. China: and ^b Department of Chemical Engineering, Inha University; Incheon 402751, Korea. * To whom correspondence should be addressed. e-mail: wdxie@sdu.edu.cn